I have WInXP. It has failed to defragment many files on the C drive for some time now, months. Can anything be done? Can the files just be deleted? I think it is leading to performance problems, as if too many Tabs are open in Chrome (especially with Facebook or other sites using Shockwave) the system really bogs down and stays down until reboot. The defragmenter always says immediately after defragmenting, if an "analysis" is done, to defragment the HDD. There's also many "REGISTRY" lines which are fragmented which it seems to not correct. Following is the last report...
Volume Windows XP (C

Volume size = 18.64 GB
Cluster size = 4 KB
Used space = 16.52 GB
Free space = 2.11 GB
Percent free space = 11 %
Volume fragmentation
Total fragmentation = 14 %
File fragmentation = 23 %
Free space fragmentation = 5 %
File fragmentation
Total files = 66,031
Average file size = 514 KB
Total fragmented files = 248
Total excess fragments = 24,665
Average fragments per file = 1.37
Pagefile fragmentation
Pagefile size = 0 bytes
Total fragments = 0
Folder fragmentation
Total folders = 9,205
Fragmented folders = 1
Excess folder fragments = 0
Master File Table (MFT) fragmentation
Total MFT size = 95 MB
MFT record count = 75,878
Percent MFT in use = 77 %
Total MFT fragments = 4
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Fragments File Size Files that cannot be defragmented
590 13 MB \WINDOWS\system32\config\systemprofile\Local Settings\Temp\Microsoft .NET Framework 2.0-KB2633880_20120522_183008931-Msi0.txt
484 13 MB \WINDOWS\system32\config\systemprofile\Local Settings\Temp\Microsoft .NET Framework 2.0-KB2518864_20120522_183423527-Msi0.txt
340 13 MB \WINDOWS\system32\config\systemprofile\Local Settings\Temp\Microsoft .NET Framework 2.0-KB2518864_20120523_071859374-Msi0.txt
242 15 MB \WINDOWS\Installer\{26A24AE4-039D-4CA4-87B4-2F83216033FF}\sp1033.MST
548 35 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1851\A0289051.dll
486 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1853\snapshot\_REGISTRY_MACHINE_SOFTWARE
492 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1854\snapshot\_REGISTRY_MACHINE_SOFTWARE
451 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1857\snapshot\_REGISTRY_MACHINE_SOFTWARE
456 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1844\snapshot\_REGISTRY_MACHINE_SOFTWARE
415 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1859\snapshot\_REGISTRY_MACHINE_SOFTWARE
388 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1858\snapshot\_REGISTRY_MACHINE_SOFTWARE
480 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1855\snapshot\_REGISTRY_MACHINE_SOFTWARE
522 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1848\snapshot\_REGISTRY_MACHINE_SOFTWARE
436 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1847\snapshot\_REGISTRY_MACHINE_SOFTWARE
444 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1849\snapshot\_REGISTRY_MACHINE_SOFTWARE
480 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1850\snapshot\_REGISTRY_MACHINE_SOFTWARE
448 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1839\snapshot\_REGISTRY_MACHINE_SOFTWARE
513 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1851\snapshot\_REGISTRY_MACHINE_SOFTWARE
424 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1840\snapshot\_REGISTRY_MACHINE_SOFTWARE
462 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1852\snapshot\_REGISTRY_MACHINE_SOFTWARE
434 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1842\snapshot\_REGISTRY_MACHINE_SOFTWARE
520 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1856\snapshot\_REGISTRY_MACHINE_SOFTWARE
393 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1841\snapshot\_REGISTRY_MACHINE_SOFTWARE
472 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1845\snapshot\_REGISTRY_MACHINE_SOFTWARE
472 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1843\snapshot\_REGISTRY_MACHINE_SOFTWARE
487 37 MB \System Volume Information\_restore{5B942C52-3EC6-4393-ADAF-2DA421A20CCE}\RP1846\snapshot\_REGISTRY_MACHINE_SOFTWARE
770 43 MB \Documents and Settings\All Users\Application Data\Microsoft\Microsoft Antimalware\Definition Updates\{0AE93540-5E63-4BDA-B6E0-187A6F73BB10}\mpavbase.vdm
649 50 MB \Program Files\Java\jre7\lib\rt.jar
240 55 MB \WINDOWS\system32\MRT.exe
382 108 MB \Program Files\Google\Chrome\Application\21.0.1180.60\Installer\chrome.7z