According the wikipedia,
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Microsoft Security Essentials (MSE) is an anti-virus computer program that provides protection against different types of malware such as computer viruses, spyware, rootkits and Trojan horses.
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There is no best security software. There are so many new malware being released everyday that security companies have a hard time capturing and analyzing so many of them. So one of the ways to evaluate security software is to find one that can best defend itself ( so that malware cannot bypass or turn it off ) so it can stay alive for another day and hope that new signatures will arrive to deal with the new malware. Fellow member "aka Brett" has done research on this and finds that ESET and Kaspersky tend to stay alive longer.
Besides antivirus and malware scanners, there is also a type of security software known as virtualization, chroot, or sandbox. For example, Sandboxie surrounds your browser so that it cannot make changes to your system, and all things downloaded or modified by your browser are confined to one folder. So you can decide to keep 1 download and wipe away all other changes by erasing that folder.
http://www.sandboxie.com/ Another example is Returnil. This software lets you run your entire system in virtual space, and all changes are gone with a reboot. Returnil also allows you to define exceptions so that for example all changes to your 'document' folder are kept, whereas all other changes are erased.
http://www.returnilvirtualsystem.com/
If you want the best security, you can add a perimeter firewall with Unified Threat Management for your network of PCs. Like Sonicwall's TZ series.
http://www.sonicwall.com/us/en/products/TZ_215.html It has intrusion prevention, gateway antivirus and antispyware, gateway URL blocking, and network technologies like wireless N, VPN and application traffic monitoring and control.