non-signature based protection works well to protect you from malware, I would suggest adding a
sandbox program I use and would suggest sandboxie the free version has a nag screen before it starts but it's not that bad,
sandboxing strengthens your security because it isolates whatever program you choose to sandbox (like your browser) from the rest of your system so that any malware that gets piked up wile browsing can't do any harm to your os ad you just delete the contents of your sandbox when you're done browsing,
also you could read up and learn about
HIPS which is what the defense+ module in comodo is, learn how to answer the prompts to the best of your knowledge and how to harden things down in the settings,
also in the comodo settings click the link "What do these settings do?" (it's on the bottom left of some of the comodo screens) to learn about the different settings in comodo,
another way to go is
Virtualization I like the program returnil with this type of program every time you restart your computer it resets everything back to when you first turned the program on so you'll be using your computer in a virtual environment, this can be troublesome because to install new programs or save new files you have to turn the program off restart your computer then install or save things then turn the rogram it back on, but if you don't change thins in your computer too often then this could work,
there's some ideas to think about from me and from Nesjemannen, and lunarlander.