I was personaly using McAfee on my old computer. Damn was it ever so slow! Whenever it was making an update, my computer slowed down. Applications would freeze. McAfee is a big system resource hog.
Now with NOD32, what a difference!
As for your problem, it may be attributed to the sleep mode. While in this mode, the computer is no longer connected to the Internet. So, when coming out of sleep, the delay for the antivirus to connect to the Web to check for updates is a little too long and it creates the error message. I have the same problem with NOD32 sometimes but it's not a serious problem because the updates will come anyway a little later. NOD32 updates many times a day without slowing down the computer. I don't even notice it. It depends how long your computer takes to come out of sleep. The longer it takes, chances are that you'll have an error message.