I highly recommend using COMODO Internet Security without Antivirus, Avira AntiVir free, and Sandboxie.
Defense plus is a HIPS application that is included in COMODO internet security, and you can disable it if you don't like it; it just adds extra layer of protection.
If you use sandboxie when you browse, when I say using sandboxie while surfing, I mean using sandboxed web browser, you shouldn't get any malwares from the internet since every activity occurs in an isolated environment.
Finally, Avira is just amazing PERIOD. By the way, if you want to disable annoying pop up you get while updating avira, just google "how to disable avira pop up."
P.S. Use Malwarebytes' anti-malware free as a backup scanner.