Hi river,
It probably means you need to Reload your repositories (Synaptic Package Manager), and then do a search for libasound2 to make sure it is available. If not, then suggest you uncomment (as root) the universe and multiverse repositories, followed by a Reload, and then search for libasound2 again.
It appears that the skype packages are in the Medibuntu repository which requires the following be added to the file /etc/apt/sources.list (Karmic Koala example), and then Reload, Search as per first paragraph:
## Medibuntu - Ubuntu 9.10 "karmic koala"
## Please report any bug on
https://bugs.launchpad.net/medibuntu/
deb
http://packages.medibuntu.org/ karmic free non-free
deb-src
http://packages.medibuntu.org/ karmic free non-free
-- Tom