This is not exactly a spam issue, but frustrating just the same.
I use Thunderbird for my email and am generally well satisfied with it.
A recent annoyance is the following:
An email sender who I did not know prior to his correspondence started sending messages of a political nature. I do not mind open and free discussion of this type, but felt obligated to respond to opinions that differed from mine. He soon responded anger-ally and resorted to name calling and blocked all of my further correspondence.
Ok, that suited me fine, since I was beginning to regard him as a bit of an intolerant fool.
The problem is, he keeps sending me his messages while my responses to cease and desist are blocked: "Remote SMTP server has rejected address".
Of course, I put a filter on his address to redirect them to trash, but I also put a Cease and Desist auto response to to his messages which causes "Delivery Notification: Delivery has failed" message coming in to my mailbox as a result of all of his new messages. The jerk continues to keep me on his address list but blocks my responses.
I guess the easiest solution is to remove my response message and just let his future messages to go into the trash folder and let that be the end of it.