Producing content, including posting here, is difficult with a touch screen. I have experimented with it, but when I use the tablet for that I usually dock it with the included keyboard (which makes it a netbook with poor balance for lap use) and sometimes add a bluetooth or USB mouse. Could also add a USB keyboard and (HDMI) external monitor and turn it into a desktop.

OK, back to my experience with Windows 7 relying on touchscreen only.
My primary difficulties, in no particular order ...
a. Typing. Better than on the smaller iPod Touch and Kindle Fire, but still a hunt and peck process for me. Don't think there's really any fix for that.
b. "Clicking" the chosen menu item. Windows 8 will be easier because of the Start screen instead of the Start menu. But I don't think there is any help for menus in general. Seems to me an option to "double space" all menus would be a decent solution. With iOS you can pinch or whatever they call it to "magnify" the display, including menus. I can't do that with Windows 7 on my Acer tablet. Maybe with Windows 8 or newer Windows touchscreens?
c. Similar to (b) selecting the desired radio button when they are small. This particularly bothers me trying to hit the little "go to first new post" symbol at the beginning of a thread title in forums here.
d. Editing text. With a mouse or touchpad I set an insert point or select text, but can't do that with a touch screen. If I needed to could probably learn new techniques, but don't know if there are any special touchscreen ways of doing that.
So, the simple answer to your hindrance question is 'yes.'