As for Kaspersky, I've tried it and didn't like it. Too many pop-ups and questions asked by the firewall. Really complicated to configure. ESET Smart Security is what I use. Simplicity, effectiveness, quickness (antivirus takes only 8 minutes to scan my whole system compared to 18 minutes for Kaspesky). NOD32 as an excellent reputation and won a lot of awards over the years.
Since I uninstalled the free trial version of Kaspersky Internet Security because of the thousands of pop-ups for every little application, I'm sure not going to try Comodo with its millions of pop-ups! They should be aware that a large part of computer users out there have no idea what to answer or how to configure the right settings. Keep it simple but effective.
Personaly, I use ESET Smart Security, combined with SuperAntiSpyware and Spywareblaster. I keep good surfing habits and stay away from porn sites and other possible malware infested websites. I keep my Windows updated for security. Oh yeah, don't forget to stay away from file sharing (P2P, torrents,...) the worst medium for infections.