computer idiot

i have been doing battle with many infections,spyware applications and hijackers i have had every thing at the worst point there was over 1000 yes i said 1000 here are just afew the wonderful DrAntispy, and of course Virus Heal, SpyWare Protection On Line, Softwareferral Zlobs galore Media codecs unfortunately am now worn down and tired in my bid to get rid of one i ended up downloading every other one. have to say Smitfraud was fun gave me false sense of security . my nod32 has been infected and wont work anymore any ideas? and im not downloading anything else till ive down research on it
please help

 

Closing duplicate thread, please continue here: http://forums.techguy.org/malware-r...adware-hijack-multiple-virus.html#post5268427