I would say no.
These programs are for finding duplicates, not to delete everything it finds.
You'll have major problems if you do.
Take a close look at what the duplicates are.
"The program has no internal decision-making to tell you what is safe to delete or not. You have to make that decision based on your knowledge and experience. If you're in doubt, do not delete the file. Take the the time to examine the folders where each set of duplicates reside and look for hard drive wasters, such as duplicate videos or image files. If one of the two files is located in the Windows folder, or any of the Windows sub-folders, I leave it alone."