External Hard Drive Pops up Very Often

My DELL OPTIPLEX 10 PRO WINDOWS 10 keeps popping up the EXTERNAL HARD DRIVE (F) while I am in Internet, is very annoying. What can I do to stop it permanently?
Your help will be greatly appreciated.
Thanks in advance.

 

Something running on your computer needs access to something that is or was on your external drive F:.

 

Thanks!!!! I wonder if It's possible to find out what exactly is causing this problem?

 

Possibly, using a bit of "process of elimination". Disable all startup programs first, reboot and see if it solves the problem. If so, you know it was one of the programs you disabled. Re-enable say three programs, reboot and test. Still no problem? Re-enable three more, reboot and test again. ... etc., etc.. When the problem does return, you know it was one of the last three startup programs you re-enabled. Disable two of those, reboot and test. If the problem is still there, you know the culprit is the one you just re-enabled. If not, re-enable one of the two left, reboot and test. ... etc. etc. ... you get the idea.

 

Still the SAME after trying your suggestion several times........ What ELSE can I try? Thanks!!! Have a peacefull weekend!!!!

 

Does the same problem occur after disabling all startup programs?

 

What browser are you using?

 

Yes!!!

 

Chrome

 

Same problem in Safe mode?

1. Press the [Windows logo key]+[I] (eye) on your keyboard to open Settings. If that doesn't work, select the Start button in the lower-left corner of your screen, then select Settings .
2. Select Update & security > Recovery .
3. Under Advanced startup, select Restart now.
4. After your PC restarts to the Choose an option screen, select Troubleshoot > Advanced options > Startup Settings > Restart.
5. After your PC restarts, you'll see a list of options. Select 4 or F4 to start your PC in Safe Mode.