For a year I've had constant mess with hard drive organization. i'd like to solve that but not sure exactly what the best setup should be for my workflow. Here is the programs I use for my business which requires both Video, Photo and Audio editing. I am using an iMac Intel Core i7 processor with 2GB of Video Ram. I have four USB 3 slots and two Thunderbolt slots which are already taken up for two display monitors. Below is the software I use and what I use each one for. Video: Premiere Pro, After Effects and Speedgrade. Footage is converted to Apple Pro Res. Photo Editing: Lightroom, Photoshop and digital scanning Audio: Avid Pro Tools, Adobe Audition CC and Reason. I edit, mix and produce music tracks and also edit audio for podcasts. Out of all those software programs I use and what I do with each one should I do this for my hard drive management? Have one External Hard Drive that holds every media file such as video, audio and photos Get a second External Hard Drive for cache files such as Render files? (known as scratch disk in Premiere.) Get a third external drive for all exports of completed media files. get a fourth external hard drive large enough to backup drives 1 through 3. I once read an article that said I should be using one external hard drive per software program. That sounds like overkill to me. Why would I need external hard drives for every program I use? Can someone please give me advice as to whether I'm in the right ballpark for finally getting my hard drives organized?