Help with pop-ud ad browser

I'm getting a pop-up advertisment browser about every 5 minutes or so. I've tried running adaware, spybot, cwshredder, regcleaner...no joy. The ads are listed in the registry as HKEY_LOCAL_MACHINE\Software\Interads\.Hotsites\.[ad name] HJT log attached. Any help as to how to get rid of this malware?

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\LEXBCES.EXE
C:\WINDOWS\system32\spoolsv.exe
C:\WINDOWS\system32\LEXPPS.EXE
C:\WINDOWS\system32\rundll32.exe
C:\Program Files\Alwil Software\Avast4\aswUpdSv.exe
C:\Program Files\Alwil Software\Avast4\ashServ.exe
C:\PROGRA~1\Iomega\System32\AppServices.exe
C:\Program Files\NMapWin\bin\nmapserv.exe
C:\WINDOWS\System32\tcpsvcs.exe
C:\WINDOWS\SYSTEM32\ZoneLabs\vsmon.exe
C:\WINDOWS\Explorer.EXE
C:\windows\system\hpsysdrv.exe
C:\Windows\system32\HpSrvUI.exe
C:\HP\KBD\KBD.EXE
C:\WINDOWS\System32\S3apphk.exe
C:\WINDOWS\System32\spool\DRIVERS\W32X86\3\printray.exe
C:\WINDOWS\System32\igfxtray.exe
C:\WINDOWS\System32\hkcmd.exe
C:\Program Files\Iomega HotBurn\Autolaunch.exe
C:\Program Files\Common Files\Real\Update_OB\realsched.exe
C:\PROGRA~1\ALWILS~1\Avast4\ashDisp.exe
C:\PROGRA~1\ALWILS~1\Avast4\ashmaisv.exe
C:\PROGRA~1\PANICW~1\POP-UP~1\PSFree.exe
C:\Program Files\LexmarkX63\AcBtnMgr_X63.exe
C:\Program Files\LexmarkX63\ACMonitor_X63.exe
C:\Program Files\Zone Labs\ZoneAlarm\zonealarm.exe
C:\PROGRA~1\ICQ\ICQ.exe
C:\Program Files\Microsoft Office\Office\OSA.EXE
C:\Program Files\Linksys\LogViewer\LogViewer.exe
C:\Program Files\Internet Explorer\iexplore.exe
C:\Program Files\Internet Explorer\iexplore.exe
C:\Documents and Settings\Owner\Desktop\HijackThis.exe

R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.cnn.com/
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyServer = 148.244.150.52:80
O3 - Toolbar: &Google - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - c:\program files\google\googletoolbar1.dll
O4 - HKLM\..\Run: [hpsysdrv] c:\windows\system\hpsysdrv.exe
O4 - HKLM\..\Run: [hp Silent Service] C:\Windows\system32\HpSrvUI.exe
O4 - HKLM\..\Run: [hpScannerFirstBoot] c:\hp\drivers\scanners\scannerfb.exe
O4 - HKLM\..\Run: [PreloadApp] c:\hp\drivers\printers\photosmart\hphprld.exe c:\hp\drivers\printers\photosmart\setup.exe -d
O4 - HKLM\..\Run: [KBD] C:\HP\KBD\KBD.EXE
O4 - HKLM\..\Run: [Recguard] C:\WINDOWS\SMINST\RECGUARD.EXE
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE NvQTwk,NvCplDaemon initialize
O4 - HKLM\..\Run: [S3apphk] S3apphk.exe
O4 - HKLM\..\Run: [PrinTray] C:\WINDOWS\System32\spool\DRIVERS\W32X86\3\printray.exe
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\System32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\System32\hkcmd.exe
O4 - HKLM\..\Run: [Drag'n'Drop_Autolaunch] "C:\Program Files\Iomega HotBurn\Autolaunch.exe"
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - HKLM\..\Run: [avast!] C:\PROGRA~1\ALWILS~1\Avast4\ashDisp.exe
O4 - HKLM\..\Run: [ashMaiSv] C:\PROGRA~1\ALWILS~1\Avast4\ashmaisv.exe
O4 - HKLM\..\Run: [Mirabilis ICQ] C:\PROGRA~1\ICQ\ICQNet.exe
O4 - HKLM\..\Run: [VBundleOuterDL] C:\Program Files\VBouncer\BundleOuter.EXE
O4 - HKCU\..\Run: [PopUpStopperFreeEdition] "C:\PROGRA~1\PANICW~1\POP-UP~1\PSFree.exe"
O4 - Startup: Office Startup.lnk = C:\Program Files\Microsoft Office\Office\OSA.EXE
O4 - Startup: PowerReg SchedulerV2.exe
O4 - Global Startup: AcBtnMgr_X63.exe.lnk = C:\Program Files\LexmarkX63\AcBtnMgr_X63.exe
O4 - Global Startup: ACMonitor_X63.exe.lnk = C:\Program Files\LexmarkX63\ACMonitor_X63.exe
O4 - Global Startup: Guidescope.lnk = C:\Program Files\Guidescope\guide.exe
O4 - Global Startup: Microsoft Office.lnk = C:\Program Files\Microsoft Office\Office\OSA9.EXE
O4 - Global Startup: ZoneAlarm.lnk = C:\Program Files\Zone Labs\ZoneAlarm\zonealarm.exe
O8 - Extra context menu item: &Google Search - res://c:\program files\google\GoogleToolbar1.dll/cmsearch.html
O8 - Extra context menu item: &NeoTrace It! - C:\PROGRA~1\NEOTRA~1\NTXcontext.htm
O8 - Extra context menu item: Allow Popups - C:\Program Files\Meaya\Popup Ad Filter\WhiteGetUrl.js
O8 - Extra context menu item: Backward Links - res://c:\program files\google\GoogleToolbar1.dll/cmbacklinks.html
O8 - Extra context menu item: Cached Snapshot of Page - res://c:\program files\google\GoogleToolbar1.dll/cmcache.html
O8 - Extra context menu item: Similar Pages - res://c:\program files\google\GoogleToolbar1.dll/cmsimilar.html
O8 - Extra context menu item: Translate into English - res://c:\program files\google\GoogleToolbar1.dll/cmtrans.html
O9 - Extra button: ICQ Pro (HKLM)
O9 - Extra 'Tools' menuitem: ICQ (HKLM)
O9 - Extra button: ICQ 4.0 (HKLM)
O9 - Extra 'Tools' menuitem: ICQ Lite (HKLM)
O9 - Extra button: MoneySide (HKLM)
O9 - Extra button: Support (HKCU)
O9 - Extra button: ComcastHSI (HKCU)
O9 - Extra button: NeoTrace It! (HKCU)
O9 - Extra button: Help (HKCU)
O10 - Unknown file in Winsock LSP: c:\windows\system32\lspak.dll
O10 - Unknown file in Winsock LSP: c:\windows\system32\lspak.dll
O10 - Unknown file in Winsock LSP: c:\windows\system32\lspak.dll
O10 - Unknown file in Winsock LSP: c:\windows\system32\lspak.dll
O16 - DPF: {74D05D43-3236-11D4-BDCD-00C04F9A3B61} (HouseCall Control) - http://a840.g.akamai.net/7/840/537/2004061001/housecall.trendmicro.com/housecall/xscan53.cab
O16 - DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) - http://fpdownload.macromedia.com/pub/shockwave/cabs/flash/swflash.cab