My wife's computer is having problems. Nothing on her desk top will open and if it does it will take forever and it will not respond once it opens. I tried to use Ad-Aware, Spyboy and EasyCleaner but it either won't open or won't respond once it opens so I did it in Safe mode and I was able to run it. I tried to remove items in the startup menu but when I restart, it appears again. I need help.