Safe Mode:
Starting in safe mode allows you to run your computer with the minimal amount of drivers utilizing only your mouse, keyboard, and monitor. It will help in troubleshooting because all other programs that are normally running in the background are shut down. You can run diagnostic software, virus scan software, while in safe mode. You can also defragment your hard drive and run a scan disk in safe mode if for some reason you are unable too in regular boot up.
Maintaining Your Computer
http://webmaxter.com/Computermain.html
How to get out of safe mode from the system configuration utility
If you use the system configuration utility to get into safe mMode you'll need to use it to get back out too.
Choose Start > Programs > Accessories > System Tools > System Information.
Choose Tools > System Configuration Utility.
On the General tab, Select Normal Startup -- Load Device Drivers and Software.
Click OK then restart Windows by clicking Yes in the System Settings Change dialog box.
Nope. Still doesn't work
If you've tried every trick in the book and still can't boot into safe mode check the following things.
Scan for viruses -- See our story on How Antivirus Works.
Check your video driver -- You must have a simple VGA video driver installed for Windows to work in safe mode.
Eliminate hardware conflicts -- See our story on device driver conflicts.