trend micro housecall has been running all night

[tallbuildings]

Following the security stickies at the top of this forum, I have been trying to run Trend Micro Housecall. It has been going all night, and is still on step 2: scanning for active grayware and spyware. On the results tab it lists
ADWARE_COMETCURSOR
ADWARE-WHENU
ADWARE_180SOLUTIONS
ADWARE-FUNWEBPRODUCTS
HTTP COOKIES

Prior to running Housecall, I ran Adaware and Search and Destroy. Adaware found some things, which I deleted. Search and Destroy found nothing.

Does Housecall usually take this long?

Should I be running these programs in safe mode?

Thanks